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Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM6331, a potential best-in-class pan-TEAD inhibitor, as a preclinical candidate compound (PCC) generated by Chemistry42, its proprietary generative chemistry-driven molecule design engine, targeting the Hippo pathway for the treatment of advanced solid tumors.

8 Jun 2023

Shifting towards precision medicine for type 2 diabetes dietary management

Researchers reviewed existing data on the genetic factors and the gene-diet interactions that could alter dietary management of type 2 diabetes.

8 Jun 2023

Study compares long-term consequences of COVID-19 between patients with rheumatic inflammatory diseases and healthy controls

Researchers used data from a long-term ongoing prospective cohort study in the Netherlands to compare the characteristics of long-COVID in inflammatory rheumatic diseases patients and healthy controls during the period when the SARS-CoV-2 Omicron subvariants, BA.1/BA.2 were dominant.

8 Jun 2023

New insights into how aggressive cancer cells proliferate and propagate the disease

Not all cancer metastases have the same destructive effect. Researchers demonstrate different mechanisms in experiments.

7 Jun 2023

Is discontinuing universal SARS-CoV-2 testing at hospital admission in England and Scotland associated with increased hospital-onset infections?

Researchers performed a time series analysis using public data sets from both nations to examine whether this discontinuation resulted in a surge in hospital-onset COVID-19 cases.

7 Jun 2023

Experts investigate the correlation between BORIS mutations and protein expression

A new research paper was published in Oncotarget's Volume 14 on May 26, 2023, entitled, "Association of mutation and expression of the brother of the regulator of imprinted sites (BORIS) gene with breast cancer progression."

6 Jun 2023

How lipid metabolites in the gut aid in regulatory T-cell differentiation

Researchers describe the Treg-cell-inducing activity of lipid extracts from the feces of specific-pathogen-free mice.

6 Jun 2023

Groundbreaking study maps molecular architecture of the visual system's integral components

A groundbreaking study has taken a significant step towards understanding the complexities of the human eye.

4 Jun 2023

How does a riboswitch regulate its own synthesis?

To prevent a global health crisis, scientists around the world are searching for ways to fight bacteria that can evade the current arsenal of antibiotics.

2 Jun 2023

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

MFAP5, a microfibril-associated protein, plays a significant role in wound healing by regulating fibroblast function, collagen deposition, and angiogenesis, suggesting its potential as a modulator of scar formation.

1 Jun 2023

NIH scientists identify genomic variants that cause rare inflammatory skin disorder

Researchers at the National Institutes of Health and their colleagues have identified genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea, and have found a potential treatment.

31 May 2023

Green Mediterranean diet reshapes DNA methylation, boosts metabolism

Study explores the effects of a green-MED diet enriched in polyphenols and reduced in red/processed meat on the methylome and transcriptome levels. It aims to uncover the molecular mechanisms underlying the observed metabolic improvements.

30 May 2023

Computational approach could help pinpoint causal variants in the noncoding genome

Less than two percent of the human genome codes for proteins, with the rest being noncoding and likely helping with gene regulation.

30 May 2023

Mice study shows how obstructive sleep apnea may affect gene activity throughout the day

The low blood oxygen levels of obstructive sleep apnea cause widespread changes in gene activity throughout the day, according to a new study in the open-access journal PLOS Biology by David Smith of Cincinnati Children's Hospital Medical Center, US, and colleagues.

30 May 2023

Interim results of the effectiveness of 2022-2023 influenza vaccine from six studies conducted in Europe

Researchers provided interim results on 2022-2023 influenza vaccine effectiveness (VE) estimates.

30 May 2023

Link confirmed: Infant RSV infections increase likelihood of childhood asthma

Research investigates the association between early-life respiratory syncytial virus (RSV) infection and the development of childhood asthma. It aims to assess the impact of RSV infection during infancy on the onset of wheezing illnesses and asthma in children.

30 May 2023

Energy drinks may stunt muscle repair, new study suggests

Energy drinks impede muscle regeneration and reduce physical performance. This study provided evidence of an inhibitory effect on myogenic differentiation and highlighted potential concerns for athletes and fitness enthusiasts.

29 May 2023

Novel treatment targets against natural killer/T-cell lymphoma identified

A team of researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has discovered that a transcription factor, TOX2, was aberrantly increased in patients with Natural killer/T-cell lymphoma (NKTL).

29 May 2023

Study highlights two strategies used by Salmonella to escape the human body's defenses

Like thieves that constantly look for ways to evade capture, Salmonella enterica, a disease-causing bacterium, uses various tactics to escape the human body's defence mechanisms.

26 May 2023

How do the outcomes of viral coinfections vary across host species?

In a recent study published in the journal PLOS Pathogens, researchers investigated the outcomes of coinfections of two viruses — Drosophila C Virus (DCV) and Cricket Paralysis Virus (CrPV) in 25 inbred lines of Drosophila melanogaster and 47 other host species belonging to the Drosophilidae family.

26 May 2023

Transcription News and Research

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Shifting towards precision medicine for type 2 diabetes dietary management

Study compares long-term consequences of COVID-19 between patients with rheumatic inflammatory diseases and healthy controls

New insights into how aggressive cancer cells proliferate and propagate the disease

Is discontinuing universal SARS-CoV-2 testing at hospital admission in England and Scotland associated with increased hospital-onset infections?

Experts investigate the correlation between BORIS mutations and protein expression

How lipid metabolites in the gut aid in regulatory T-cell differentiation

Groundbreaking study maps molecular architecture of the visual system's integral components

How does a riboswitch regulate its own synthesis?

MFAP5, a microfibril-associated protein, unveiled as key player in scar formation and wound healing

NIH scientists identify genomic variants that cause rare inflammatory skin disorder

Green Mediterranean diet reshapes DNA methylation, boosts metabolism

Computational approach could help pinpoint causal variants in the noncoding genome

Mice study shows how obstructive sleep apnea may affect gene activity throughout the day

Interim results of the effectiveness of 2022-2023 influenza vaccine from six studies conducted in Europe

Link confirmed: Infant RSV infections increase likelihood of childhood asthma

Energy drinks may stunt muscle repair, new study suggests

Novel treatment targets against natural killer/T-cell lymphoma identified

Study highlights two strategies used by Salmonella to escape the human body's defenses

How do the outcomes of viral coinfections vary across host species?

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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