Efficacy News and Research

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Gut health boost: Functional foods and herbs show promise in tackling SARS-CoV-2 variants

Functional foods and natural herbs have the potential to enhance immune function and maintain gut microbiota diversity. This review explores their role in mitigating the impact of SARS-CoV-2 variants on gut health and overall well-being.

8 Jun 2023

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM6331, a potential best-in-class pan-TEAD inhibitor, as a preclinical candidate compound (PCC) generated by Chemistry42, its proprietary generative chemistry-driven molecule design engine, targeting the Hippo pathway for the treatment of advanced solid tumors.

8 Jun 2023

UC research examines role of a metabolite in the development of abdominal aortic aneurysm

Each year, about 200,000 people in the United States are diagnosed with a bulge in the lower part of the aorta, the main artery in the body, called an abdominal aortic aneurysm (AAA).

8 Jun 2023

Yellow fever: examining potential burden on vaccine strategy

Researchers presented a stochastic model of yellow fever transmission.

8 Jun 2023

Targeted therapy for non-small cell lung cancer provides benefit to patients after surgery

A clinical trial led by Yale Cancer Center shows that the drug osimertinib, a targeted therapy for non-small cell lung cancer, improved rates of survival and reduced risk of recurrence in patients after surgery.

7 Jun 2023

Diabetes drug reduces alcohol drinking by more than half in rats

The medication semaglutide, which is currently used in the treatment of type 2 diabetes and obesity, might also be an effective medication for alcohol dependence.

7 Jun 2023

Patients with high-risk chronic lymphocytic leukemia may benefit from treatment with ibrutinib plus venetoclax

First-line ibrutinib (Imbruvica) plus venetoclax (Venclexta) led to high response and survival rates in patients with chronic lymphocytic leukemia (CLL) whether or not their cancer harbored high-risk genetic features typically associated with poor outcomes, according to results published in Clinical Cancer Research, a journal of the American Association for Cancer Research (AACR).

7 Jun 2023

Gene drive technology could help eradicate malaria

Population-level changes in the genetic make-up of one of the world's deadliest animals could provide a key in the fight against malaria, proponents of a radical new technology argue.

7 Jun 2023

Axol Bioscience collaborates with StrataStem to deliver stem cell based ‘clinical trial in a dish’ for Alzheimer’s disease

Axol Bioscience Ltd. (Axol), a leading pluripotent stem cell technology provider for drug discovery has signed an exclusive agreement with StrataStem to access and commercialize its extensive collection of Alzheimer’s Disease (AD) patient samples.

From Axol Bioscience Ltd 7 Jun 2023

Estimate of treatment effect modification by comorbidity using participant data

Treatment efficacy for a broad range of chronic diseases does not differ depending on patients' comorbidities, according to a new study publishing June 6th in the open access journal PLOS Medicine by David McAllister of the University of Glasgow, UK, and colleagues.

7 Jun 2023

New strategy to grow and measure how tumor organoids respond to therapy

Scientists from the UCLA Jonsson Comprehensive Cancer Center have developed a new method to bioprint miniature tumor organoids that are designed to mimic the function and architecture of real tumors. The improved process allows researchers to use an advanced imaging method to study and analyze individual organoids in great detail, which can help researchers identify personalized treatments for people with rare or hard-to-treat cancers.

7 Jun 2023

Oral semaglutide outperforms other medications in type 2 diabetes treatment, significantly reducing HbA1c and body weight

Orally administered semaglutide shows significant efficacy in reducing HbA1c and body weight in patients with type 2 diabetes compared to other treatments. The study includes a large number of participants from multiple trials.

7 Jun 2023

CBD and EPA cream: Dynamic duo for youthful skin

A recent study examines the anti-aging potential of a new cream formulation that contains CBD and EPA.

6 Jun 2023

New folate-targeting magnetic microrobot system shows great potential in cancer treatment

The limited ability of microrobots to assist drugs in entering cells hinders their therapeutic efficacy. To address this, the cancer-targeting molecule folic acid (FA) was introduced to microrobots to promote drug uptake by cancer cells via receptor-ligand-mediated endocytosis.

6 Jun 2023

The phenolic composition, antioxidant capacity, and other functional properties of fresh and dried figs

Researchers explored the phytochemical contents and health benefits of consuming figs.

6 Jun 2023

Endophytic fungi Penicillium verhagenii: an exploration of its anticancer, antioxidant, antimicrobial, and larvicidal activity

Researchers explored the use of endophytic fungi to fabricate selenium nanoparticles.

6 Jun 2023

Microparticle-delivered therapy likely to be the first step toward stopping autoimmune diseases

According to the federal government's National Institute of Neurological Disorders and Stroke, nearly 3 million people worldwide -; with almost a third in the United States -; are living with multiple sclerosis (MS), a disabling neurological disease in which the body's immune system mistakenly attacks nerves feeding information to the central nervous system (the brain and spinal cord). Although rarely fatal, MS can lead to long-term disabilities, and impair movement, muscle control, vision and cognition.

6 Jun 2023

Study assesses the safety, efficacy of using immune checkpoint inhibitors in patients with advanced kidney cancer

Patients with advanced kidney cancer are routinely given immune checkpoint inhibitors (ICIs) as first-line treatment.

5 Jun 2023

Simple blood test for the diagnosis of Glut1 deficiency syndrome

Glut1 deficiency syndrome is a rare and disabling neurological disease still relatively unknown to the medical community.

5 Jun 2023

Study provides a treasure trove of information on molecular biology of the immune system

Researchers at Sanford Burnham Prebys, collaborating with scientists from Eli Lilly and Company, have revealed the structure and function of a drug called LY3361237, which can reduce the harmful activity of the immune system to help treat autoimmune diseases.

5 Jun 2023

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Efficacy News and Research

Gut health boost: Functional foods and herbs show promise in tackling SARS-CoV-2 variants

Insilico Medicine nominates pan-TEAD inhibitor as a potential solution for drug resistance in solid tumor patients

UC research examines role of a metabolite in the development of abdominal aortic aneurysm

Yellow fever: examining potential burden on vaccine strategy

Targeted therapy for non-small cell lung cancer provides benefit to patients after surgery

Diabetes drug reduces alcohol drinking by more than half in rats

Patients with high-risk chronic lymphocytic leukemia may benefit from treatment with ibrutinib plus venetoclax

Gene drive technology could help eradicate malaria

Axol Bioscience collaborates with StrataStem to deliver stem cell based ‘clinical trial in a dish’ for Alzheimer’s disease

Estimate of treatment effect modification by comorbidity using participant data

New strategy to grow and measure how tumor organoids respond to therapy

Oral semaglutide outperforms other medications in type 2 diabetes treatment, significantly reducing HbA1c and body weight

CBD and EPA cream: Dynamic duo for youthful skin

New folate-targeting magnetic microrobot system shows great potential in cancer treatment

The phenolic composition, antioxidant capacity, and other functional properties of fresh and dried figs

Endophytic fungi Penicillium verhagenii: an exploration of its anticancer, antioxidant, antimicrobial, and larvicidal activity

Microparticle-delivered therapy likely to be the first step toward stopping autoimmune diseases

Study assesses the safety, efficacy of using immune checkpoint inhibitors in patients with advanced kidney cancer

Simple blood test for the diagnosis of Glut1 deficiency syndrome

Study provides a treasure trove of information on molecular biology of the immune system

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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