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Study reveals factors impacting pertussis antibody half-lives in infants, sheds light on preterm infants' resilience

Researchers compared two methods of half-life estimation to evaluate the half-life of maternal antibodies.

9 Jun 2023

MIS-C in children: A distinct autoimmune response to COVID-19 unveiled

The study reveals that MIS-C patients, post SARS-CoV-2 infection, develop a unique immune response against the virus' N protein, indicating a cross-reactivity with the self-protein SNX8, which might link the infection to the ensuing inflammatory syndrome.

8 Jun 2023

Scientists unlock virus-fighting power with synthetic nanobody platform

Discovery and validation of nanobodies, a promising class of biologics, for viral infection prevention and treatment, including anti-SARS-CoV-2 nanobodies with enhanced neutralization properties through synergistic pairing. The study demonstrates the potential of nanobodies in developing effective therapies against viral infections.

8 Jun 2023

New folate-targeting magnetic microrobot system shows great potential in cancer treatment

The limited ability of microrobots to assist drugs in entering cells hinders their therapeutic efficacy. To address this, the cancer-targeting molecule folic acid (FA) was introduced to microrobots to promote drug uptake by cancer cells via receptor-ligand-mediated endocytosis.

6 Jun 2023

SickKids scientists shine light on the complex genetics that underlie blood pressure regulation

Scientists at The Hospital for Sick Children (SickKids) are delving deep into the non-coding genome to unravel the complex genetics that underlie blood pressure regulation and hypertension (high blood pressure) – the leading cause of cardiovascular disease affecting 1.25 billion people worldwide.

6 Jun 2023

How lipid metabolites in the gut aid in regulatory T-cell differentiation

Researchers describe the Treg-cell-inducing activity of lipid extracts from the feces of specific-pathogen-free mice.

6 Jun 2023

A SARS-CoV-2 spike-targeting bispecific T-cell engager strategy for controlling SARS-CoV-2 infection

Researchers described a novel strategy for controlling severe acute respiratory syndrome coronavirus 2.

5 Jun 2023

MatTek and AIM Biotech Partner on Advanced 3D Tissue Culture Organ-on-a-Chip Systems

Today, MatTek Life Sciences and AIM Biotech announced a strategic partnership through which the AIM Biotech portfolio will be available for sale through MatTek.

From MatTek Corporation 2 Jun 2023

Wastewater data unveils underreported Mpox cases in Texas

A recent study characterizes the analytical sensitivity of three assays used to detect MPXV in wastewater samples.

31 May 2023

CSEM collaborates with innovative Swiss start-up MOMM diagnostics to introduce revolutionary preeclampsia test

CSEM’s Tools for Life Sciences team is partnering with MOMM Diagnostics to develop a cutting-edge point-of-care solution for preeclampsia diagnostics. This ground-breaking multiplexed sensing device simultaneously detects two crucial biomarkers associated with this prevalent disease.

From CSEM 31 May 2023

Biomarker study reveals the effects of astrocyte reactivity in preclinical Alzheimer's disease

Evidence supports a close link between Aβ, astrocyte reactivity, and tau pathology in preclinical AD.

31 May 2023

Link confirmed: Infant RSV infections increase likelihood of childhood asthma

Research investigates the association between early-life respiratory syncytial virus (RSV) infection and the development of childhood asthma. It aims to assess the impact of RSV infection during infancy on the onset of wheezing illnesses and asthma in children.

30 May 2023

Artificial intelligence in sperm selection for assisted reproduction

Researchers summarize available evidence on the application of artificial intelligence and machine learning in sperm selection.

29 May 2023

Novel assay for identifying individuals with synucleinopathies using serum samples

Synucleinopathies are a group of neurodegenerative diseases caused by the abnormal accumulation α-synuclein, a protein normally found in the brain and neurons. Incorrect folding of α-synuclein leads to formation of 'seeds', which attract more α-synuclein proteins to form larger clumps.

29 May 2023

Gut bacteria toxins: A hidden trigger for Parkinson's disease?

Gut dysfunction and the presence of lipopolysaccharide (LPS) endotoxins contribute to the pathogenesis of Parkinson's disease (PD), leading to neuroinflammation and neurodegeneration. Modulating the gut microbiome and reducing LPS levels may hold potential as treatment strategies for PD.

24 May 2023

Surviving without glucose: uridine-derived ribose as an alternative energy source

Researchers attempted to identify new genes and molecular pathways that might supply energy when the availability of glucose or other nutrients is limited.

22 May 2023

Study shows the potential of TAp63 as a new therapeutic target for rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint deterioration. The clinical outcomes of patients with active RA can be improved using anti-rheumatic medications, such as methotrexate (MTX).

22 May 2023

Cross-reactivity between Epstein-Barr virus and protein in multiple sclerosis sheds light on disease development

Research uncovers the association between multiple sclerosis (MS) and antibody reactivity to specific amino acids in CRYAB, along with the increased risk when combined with high EBNA1 responses. The study provides evidence of antibody and T cell cross-reactivity between EBNA1 and CRYAB, highlighting the role of EBV adaptive immune responses in MS development.

21 May 2023

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Research describes the development of a synthetic delivery vector called STxB for mucosal vaccination. It induces mucosal immunity, including resident memory CD8+ T cells and IgA antibodies, against antigens derived from mucosal viruses when administered intranasally in mice.

21 May 2023

Efficient assay system aids rapid genetic diagnosis of mitochondrial diseases

The gene ECHS1 encodes for enoyl-CoA hydratase short-chain 1, a mitochondrial enzyme involved in branched-chain amino acid and fatty acid metabolism.

18 May 2023

Assay News and Research

Study reveals factors impacting pertussis antibody half-lives in infants, sheds light on preterm infants' resilience

MIS-C in children: A distinct autoimmune response to COVID-19 unveiled

Scientists unlock virus-fighting power with synthetic nanobody platform

New folate-targeting magnetic microrobot system shows great potential in cancer treatment

SickKids scientists shine light on the complex genetics that underlie blood pressure regulation

How lipid metabolites in the gut aid in regulatory T-cell differentiation

A SARS-CoV-2 spike-targeting bispecific T-cell engager strategy for controlling SARS-CoV-2 infection

MatTek and AIM Biotech Partner on Advanced 3D Tissue Culture Organ-on-a-Chip Systems

Wastewater data unveils underreported Mpox cases in Texas

CSEM collaborates with innovative Swiss start-up MOMM diagnostics to introduce revolutionary preeclampsia test

Biomarker study reveals the effects of astrocyte reactivity in preclinical Alzheimer's disease

Link confirmed: Infant RSV infections increase likelihood of childhood asthma

Artificial intelligence in sperm selection for assisted reproduction

Novel assay for identifying individuals with synucleinopathies using serum samples

Gut bacteria toxins: A hidden trigger for Parkinson's disease?

Surviving without glucose: uridine-derived ribose as an alternative energy source

Study shows the potential of TAp63 as a new therapeutic target for rheumatoid arthritis

Cross-reactivity between Epstein-Barr virus and protein in multiple sclerosis sheds light on disease development

Synthetic delivery vector STxB induces mucosal immunity against viral antigens

Efficient assay system aids rapid genetic diagnosis of mitochondrial diseases

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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